Evaluating the efficacy of flavonoids from Capparis spinosa extracts in treatment of Candida vulvovaginitis

Flavonoids were extracted from the leaves and stems of the Capparis spinosa (Caper) plant. The total flavonoids were detected with qualitative and quantitative assays. C. albicans isolates were isolated from patients infected with vaginal candidiasis and these fungal isolates revealed high levels of biofilm formation. Flavonoids isolated from the leaves and stems of the C. spinosa plant were found to have antibiofilm activity against all C. albicans isolates dependent on dose manner. In comparison to the control, flavonoids influence all C. albicans, at 400 µg mL-1, with percentages of biofilm inhibition ranging from 69 to 31%. These findings imply that flavonoids could be useful in treating biofilm-associated C. albicans infections to overcome the difficulties associated with multi-antibiotic resistance.