Comparison of irreversible symptomatic pulpitis in deciduous and permanent teeth regarding the presence and concentration of immunoglobulins

On the basis of current data, the correlation between symptomatic pulpitis of deciduous teeth and presence or concentration of different immunoglobulins was not studied up to now. So the aim of this study was to investigate the correlation between presence or concentration of IgG, IgA, IgM and IgE and symptomatic pulpitis in deciduous teeth. Methods & Materials: For this purpose, in this analytical (case-control) study, 22 pulpal samples with irreversible symptomatic inflammation from 11 deciduous teeth and 11 permanent teeth were collected. After culturing them for 3 days, SRID method was used for detecting the amount of IgG, IgA and IgM and ELISA was used for measuring the amount of IgE in supernatant fluids. Mann – whitney U, Exact Fisher and Spearman correlation test were used to show the difference. The presence of IgG, IgA, IgM and IgE in the deciduous samples was 27.3%, 0%, 0% and 54.5%, respectively, with mean concentration of 1721.41± 3384.46 mg/100ml, 0, 0 and 0.36± 0.56 IU/ml. The presence of IgG, IgA, IgM and IgE in permanent samples was 54.5%, 18.2%, 9.1% and 54.5% respectively with mean concentration of 2688.96± 2631.39, 38.84± 87.93, 47.15± 156.38 mg/100ml and 0.27± 0.38 IU/ml. Statistical analysis did not show any significant difference between deciduous and permanent teeth regarding to presence or concentration of immunoglobulins. It is suggested that in symptomatic pulpitis in both types of dentition, humoral immune response is involved. Of course further study is needed in order to prove this hypothesis.