Subtype distribution of Blastocystis sp. isolated from humans in Iran: a systematic review and meta-analysis
This systematic review and meta-analysis evaluated the subtyped Blastocystis sp.isolated from humans in Iran.
Blastocystis sp.is an anaerobic intestinal protozoan that infects humans as well as domestic and wild animals, i.e. mammals, amphibians, reptiles, and arthropods.
A comprehensive search for papers published before April 2022 was undertaken utilizing English and Persian databases. The following MeSH keywords were used in the electronic search: (Blastocystissp.) AND (molecular OR subtype) AND (prevalence OR epidemiology) AND Iran. The quality of the included studies was evaluated.Thereafter, a random-effects meta-analysis was conducted to estimate the pooled prevalence and odds ratios regarding the included studies.
A total of 32 studies comprised of five case-control studies and 27 cross-sectional studiesmet the eligibility criteria. The overall pooled prevalence of subtyped Blastocystissp. in Iran was estimated to be 10% (95% confidence interval: 6 to 15%). Eight subtypes of Blastocystissp. (ST1-ST7 and ST9)were identified in our study,of which ST3was the most common subtype (0.04); 0.02-0.07). The difference in subtypes between two case and control groups in reported studies was not significant, but the odds ratio of infection by ST3 (0.98; 95% CI, 0.30 to 3.20) was higher in cases.
The current systematic review showed that with the exception of ST8 and ST12, all human Blastocystissp. subtypes reported in the world are found in different parts of Iran.
Blastocystis , Subtype , Meta-analysis , Iran
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