Application of N-isocyaniminotriphenyl phosphorane for preparation of heterocyclic acrylate as a key constituent of many industrial and pharmaceutical compounds
2-Hydroxy pyridine undergoes a smooth reaction with electron-deficient acetylenic esters in the presence of N-isocyaniminotriphenyl phosphorane under reflux conditions to produce the heterocyclic acrylate compounds in high yields. The acrylate structures with E/Z isomers were obtained when the reaction was performed with 4-Hydroxy pyridine and 4-Hydroxy quinazoline, the acrylate structures with E/Z isomers were obtained. All compounds have many applications in medicinal and industrial chemistry—configuration of E/Z isomers distinguished with nuclear magnetic resonance technique and chemical shift of olefinic proton. The method offers a simple and efficient route for preparing acrylate heterocyclic compared to the other methodologies. The structures of the products were deduced and supported by 1HNMR and IR spectroscopy.
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