Gamma-Aminobutyric Acid Type A Receptor Subunit Delta (GABRD) Inhibits Breast Cancer Progression by Regulating the Cell Cycle

The role of γ-aminobutyric acid receptor (GABR) in breast cancer (BC) is unknown.

The expression of different GABR subunits between BC and adjacent normal tissues was compared using transcriptome data set. The clinical and prognostic importance of the various GABR subunit genes in BC was determined using clinical and survival data (Data downloaded from TCGA, May 2022). Only GABRD was discovered to be substantially expressed and strongly related to the prognosis of BC cases.

Compared with normal tissues, GABRD expression was increased in all subgroups of breast cancer tissues. Knockdown of GABRD inhibited the growth of BC cells. Mechanistically, the function of GABRD may be attributed to its effect on major pathways such as oxidative phosphorylation, Parkinson disease, and cell cycle. GABRD deletion significantly blocked the G2/M phase in BC cells.

Overall, GABRD might be a novel prognostic predictor of BC, providing clues for further studies on GABRD.