No change in HDL in the presence of increased paraoxonase-1 in response to TRX training in obese middle-aged obese women

Scientific evidence suggests a reduction in the anti-atherogenic and antioxidant effects of paraoxonase-1 (PON1) in the presence of obesity. The aim of this study was to determine the effect of 8 weeks TRX on PON1 and HDL in inactive middle-aged obese women.

For this purpose, 28 sedentary middle-aged obese women aged 30-40 years of old (30 ≤ BMI ≤ 36) were randomly divided into of TRX (8 weeks, 3days/weekly, n= 14) and control (no training, n = 14) groups. Fasting levels of PON1 and HDL and anthropometric indices (Weight, abdominal circumference, body mass index, visceral fat, body fat percentage) were measured before and 48 hours after lasted exercise session in both groups. Independent and paired t-test was used to compare baseline levels and changes in variables between the two groups before and after the training program.

TRX training led to a significant increase in PON1 (p= 0.016) a significant decrease in anthropometric indices (p < 0.05) and but HDL did not change significantly (p = 0.087). None of these variables were changed in the control group (p > 0.05).

Despite no change in HDL, TRX training by increasing PON1 is associated with antioxidant and anti-atherogenic effects in obese middle-aged women.