Effect of exercise activity with different intensity and volume on the expression of PDGF-B and FGF-2 genes in subcutaneous adipose tissue o f Wistar rats.

Obesity is the cause of various diseases and in this regard, the growth of adipose tissue is associated with changes in angiogenesis. The effect of exercise on regulation of adipose tissue angiogenesis has been shown by some studies. The aim of the present study was to investigate the effect of exercise activity with different intensity and volume on the expression of PDGF-B and FGF-2 genes in subcutaneous adipose tissue of Wistar rats.

In this experimental study 24 rats (8 weeks old weighing 237±33 g) were kept under standard conditions and were randomly divided into 3 groups High Intensity Interval Training, Moderate Intensity Training and Control. HIIT (28 minutes, including 4 intervals of high intensity at 90 to 100% VO2max and low intensity at 50 to 60% VO2max) and MIT (37 minutes with an intensity of 65% VO2max) groups underwent 8 weeks exercise training. Tissue sampling was performed 24 hours after the last exercise training session and expression of PDGF-B and FGF-2 genes were measured by qRT-PCR. One-way ANOVA and Tukey post-hoc tests were used to analyze the data at the significance level of α <0.05.

The results showed that HIIT and MIT significantly increased PDGF-B and FGF-2 gene expression in rat adipose tissue compared to the control group (both P=0.001).

It seems that according to the findings of the present study, both training protocols have the same effects on the process of angiogenesis of subcutaneous adipose tissue.