Investigating the effect of cytotoxicity of nanonisome containing the extract of Artemisia annua on breast cancer cell lines

Niosomes are primary-bilayer vesicles used in anticancer drugs. The aim of this study is the synthesis of nisome nanocarrier containing Artemisia Annua extract and its anticancer charactersitics.

This in-vitro study was carried out at the Islamic Azad University, North Tehran Branch, from December 1400 to September 1401. Firstly, a niosomes nanocarrier was synthesized with the thin-layer hydration approach. Then, Artemisia Annua extract was loaded into them. Following that, physical and chemical features of nanocarriers were evaluated utilizing scanning electron microscope (SEM) and dynamic light scattering (DLS). The encapsulation level and the release pattern of the extract were valiadated vi a dialysis bag. Finally, its anticancer effects were investigated on breast cancer cell line (MCF_7).

The results showed that the synthesized nanocarrier of nisome containing the extract has a spherical structure and its size was 208.1 nm and the encapsulation percentage was 62.35%. It was also found that the nanocarrier of loaded niosom had significant anticancer effects compared to non-loaded extract.

It can be concluded that the nisome-containing Artemisia Annua extract of medicinal plant increases the anti-cancer effects significantly, and therefore, nisome can be used as a targeted drug delivery system for anti-cancer purposes.