Causal relationship between Depression and Health-related quality of life through chain mediation of Chronic Fatigue and Treatment Adherence in women with uterine cancer

The aim of the present study was to investigate the causal relationship between depression and health-related quality of life through the chain mediation of chronic fatigue and adherence to treatment in women with uterine cancer.

In this descriptive correlational study, the statistical population consisted of all women diagnosed with uterine cancer in Mashhad in the year 2021, and 261 people were selected as a sample by purposive sampling. In this study, Health-related quality of life of Weber (1992), Depression of Beck (1996), Chronic fatigue of Chalder et al (1993), Treatment Adherence of Seyyed Fatemi, Rafiei, Hajizadeh & Madanlo (2018) were used for data collection in this study. The data were analyzed using Pearson's correlation coefficient and path analysis model with the help of SPSS-27 and AMOS-25 software.

The findings showed the relationship between depression and health-related quality of life; between depression and chronic fatigue; between chronic fatigue and adherence to treatment; There was a significant relationship between adherence to treatment and health-related quality of life (p<0.01); Also, the indirect path of depression with health-related quality of life with the mediating role of chronic fatigue and adherence to treatment were significant (p<0.01).

Based on the results of this research, the proposed model had a favorable fit and is considered an important step in the direction of knowing the factors affecting the quality of life related to the health of women with uterine cancer.