Study of Scrophularia striata effects on histomorphometrical changes of the endocrine adrenal tissue in rat following experimental diabetes type2

Type 2 diabetes is a metabolic disorder that may have negative effects on the structure of the adrenal gland. Nowadays, herbal medicines, including Scrofularia striata, are prescribed in the treatment of many diseases.

In this study, 32 adult male Wistar rats were divided into 4 groups of 8. Control: The diabetic group was fed a high-calorie diet containing 20% cow fat, 20% sucrose, and 60% normal diet for 6 weeks, and then streptozotocin drug was injected intraperitoneally at the rate of 20 mg/kg. Diabetes-Scrofularia striata group: This group was given a high-calorie diet for 6 weeks, and then streptozotocin drug was injected at the rate of 20 mg/kg. Then (in addition to receiving a high-calorie diet), the hydroalcoholic extract of Scrofularia striata plant at the rate of 400 mg/kg was given by gavage daily for 28 days. Scrofularia striata group: This group was given 400 mg/kg of Scrofularia striata plant extract daily for 28 days along with the usual.

In the diabetic group, the diameter of the layers of the cortical part of the adrenal gland increased, but the diameter of the central part showed a significant decrease, compared to the control group. Following the consumption of Scrofularia striata, the diameter of cortical layers in the diabetes-Scrofularia striata group showed a significant decrease compared to the diabetes group, but the diameter of the central part showed a non-significant increase.

Scrofularia striata have beneficial effects on the structural changes caused in the adrenal gland.