Case Series of Cerebral Venous Sinus Thrombosis After COVID-19 Vaccination

While care for COVID-19 patients has improved with clinical experience, there remains a critical and unmet medical need for vaccines suitable to help or alleviate COVID-19 infections during the pandemic. Although the available vaccines have some benign autoimmune side effects, such as mild thrombocytopenia, in rare cases, the side effects, such as central vein thrombosis, severe thrombocytopenia, and intracranial hemorrhage, are lifethreatening.

We report 3 female patients (19, 24, and 43 years old) who developed cerebral venous sinus thrombosis (CVST) after the AstraZeneca ChAdOx1-S COVID-19 vaccination. Despite medical and surgical treatment, they finally became brain dead.

Medical professionals should know the manifestations and diagnostic methods of CVST after the COVID-19 vaccination and how to properly treat and manage it.