Investigation on the Effect of Different Selenium Sources on Some Mineral Elements and Antioxidants in the Blood of Fars kaboodeh Lambs

Selenium is an essential trace element for many physiological processes, especially for the functioning of the immune and reproductive systems, the metabolism of thyroid hormones, and antioxidant defense. This study was performed to investigate different sources of selenium on some mineral elements and antioxidants in the blood of Fars kaboodeh lambs. In this experiment, sixteen 4-month-old Fars kaboodeh lambs with an average weight of 35±2 kg were used. At the beginning of this study, the lambs used for plaque were first weighed and subjected to clinical examination. The treatments tested included sodium selenite and nano-selenium orally at the rate of one-tenth of a milligram per kilogram of body weight for ten days, vitamin E selenium (injectable at a rate of 0.005 mg per kilogram of live weight), and the control group (without selenium). Water and salt were provided ad libitum to the animals. The basic diet was performed twice a day (8:00 am and 6:00 pm) based on racial needs and feeding. The duration of the experiment was 30 days and blood sampling of lambs was performed on the days of the experiment (zero), 10 and 30 days. The concentrations of iron, copper and zinc under the influence of different sources of selenium showed a significant difference (P<0.05). In general, the use of different sources of selenium decreased the concentration of iron, copper and increased the concentration of plasma in different periods of the experiment. Blood selenium of lambs during the experiment also showed a significant difference (P<0.05) and its amount increased during the experiment. The activity of glutathione peroxidase and superoxide dismutase also increased under the influence of different sources of selenium (P<0.05). In general, the use of different sources of selenium decreased the concentration of iron and copper in serum in the 1st, 2nd, and 3rd periods and the concentration of zinc in different periods of the experiment showed a significant increase. By raising the expression of transferrin receptors on the surface of tissue cells, selenium enhances the entry of transferrin into the cell by receptor-mediated endocytosis, which reduces the serum iron concentration. On the other hand, iron deficiency affects the production of ceruloplasmin and this protein is responsible for copper transport. Copper changes may have an indirect effect on serum concentrations. The absorption of copper on the intestinal surface is impaired by increasing the synthesis of metallothionein. The use of different sources of selenium caused a continuous supply of selenium and reached the desired level of plasma selenium concentration. The increase in glutathione peroxidase levels is due to a direct correlation between selenium concentration and glutathione peroxidase activity. In general, the use of selenium improves the performance and health of lambs.