The effect of high-intensity interval training on serum Asprosin and lipid profile of overweight and obese women

Asprosin where secreted from adipose tissue plays a key role in regulating glucose metabolism and appetite, and could be a therapeutic target for the prevention of diseases such as obesity, type II diabetes, and insulin resistance. Therefore, the present study aimed to investigate the effect of high-intensity interval training (HIIT) on serum Asprosin and lipid profile in overweight and obese women.

Thirty overweight and obese women (BMI≥28) with an age range of 30-45 years were purposefully selected in a quasi-experimental research with pre - test to post-test design. They randomly divided into two groups including 15 subjects in every HIIT and control group. The protocol was included preparation period for two weeks, eight weeks for the HIIT, and also they performed three sessions per week with 100% maximum reserve heart rate. Blood samples were taken before and 48 hours after the last training session (following 10 weeks of training). The amount of Asprosin and lipid profile were measured by ELISA and spectrophotometry methods respectively. Data were analyzed using Independent t-test and paired sample t-test at a significant level of p<0.05.

After 10 weeks of intervention, HIIT group showed a significant decrease in amount of Asprosin (p=0.02), triglyceride (p=0.01), total cholesterol (p=0.01), low density lipoprotein cholesterol (p=0.01), very low density lipoprotein cholesterol (p=0.01), weight (p=0.0001), fat percentage (p=0.0001) and BMI (p=0.0001), but a significant increase also observed in maximal oxygen consumption (p=0.0001). However, no significant increase in high density lipoprotein cholesterol (p>0.05) was observed.

Probably HIIT as a non-pharmacological and effective method can reduce serum Asprosin and lipid profile in overweight and obese women and therefore improve their body composition.