Examining the Serum Levels of D-Dimer, Fibrinogen, and Interleukin-6 as Indicators for Timely Treatment of COVID-19 Patients

The COVID-19 pandemic, caused by the coronavirus, has emerged as one of the most pressing healthcare challenges of this century. The role of laboratory data in diagnosing severe forms of COVID-19 remains inconclusive. This research aimed to find ways to quickly prevent COVID-19. This research involved 43 COVID-19 patients monitored from March 2022 to May 2022 at the Mehregan Private Center in Khuzestan Province. Hematological and biochemical tests of the patients were performed. Measurements of D-dimer and Interleukin-6 were performed using the Biotek ELX 800TS analyzer, while fibrinogen levels were determined through the Clauss coagulation method. Data analysis was carried out using SPSS version 22 and GraphPad Prism version 9. There is a significant difference in the levels of interleukin 6, D-Dimer, and fibrinogen, which was equal to 0.0001 (P<0.05). Threshold level and area under the receptor operating characteristic curve (ROC) interleukin-6 was 20.06 pg/ml and 0.837, D-dimer 952.5 ng/ml and 0.929, and fibrinogen was 206.5 mg/dL and 0.768, respectively. The specificity and sensitivity of predicting the severity of COVID-19 interleukin 6 were 67.44% and 100%, D-dimer 60.47% and 97.67%, and fibrinogen 53.49 % and 95.35%, respectively. Interleukin-6 and D-dimer had the highest specificity and sensitivity for early prediction of the severity of COVID-19, but for fibrinogen, this level was not as obvious as the other two factors. D-dimer and interleukin-6 had more pronounced effects on the             severity of this disease, while fibrinogen had a lower impact.