The investigation of relation between learning and sensitivity to chemical kindeling with Pentylenetetrazole in male rats

Epilepsy is one of the most common afflictions of human. The amygdala is one of the most sensitive epilepsy induction areas. This area has been the focus of interest, in large part due to its role in fear conditioning. It seems that any abnormality in the neuronal network in amygdala can increase the susceptibility of animal to seizure. The purpose of the present study was to evaluate the relationship between avoidance learning and kindeling susceptibility in rats. In an experimental study, 20 Wistar male rats were trained for two way active avoidance learning in the shuttle box, and on the basis of escape response were divided into fast and slow learning animals. The rats were administered Pentylenetetrazole for induction of kindeling. Then seizure stages were noted. Data was analyzed using one way ANOVA and Tukey's test. Results of the present study demonstrated that slow learning animals comparing to fast learnings were more prone to kindeling and there was a significant difference in the seizure stage and stage 2 latency in the two groups. On the basis of the present data it is possible to predict the predisposing of male rats to kindeling from the rate of fear conditioning that indicates the abnormality in amygdala neuronal circuits