Formulation of an injectable implant for peptid delivery and mechanistic study of the effect of polymer molecular weight on its release behavior
Author(s):
Abstract:
The effects of polymer molecular weight on drug release from erodible matrices are not well known. It would be more complicated for in-situ forming injectable implants that change gradually from liquid to solid after injection. To investigate this phenomenon, two commerciallyaavailable PLGA polymers (lactic acid-co-glycolic acid) with molecular weights of 12000 and 48000 Da were used to prepare injectable implants containing leuprolide acetate as a model peptide. The influence of polymer molecular weight on the morphology and erosion of matrices and also on their in-vitro drug release behavior over a period of 28 days was investigated. Results showed that the amount of drug released (32%) over the first 24 hours (burst phase) for 12 kDa PLGA system, was significantly (P<0.05) higher than that of the one higher molecular weight (13%). There was no difference between the steady-state release fluxes of drug from the systems. Erosion profiles were also in agreement with those of release behavior in both burst and steady-state phases. Electron microscopy studies showed that the lower molecular weight system is more porous than the higher one, which can explain the difference between burst effects.
Language:
English
Published:
DARU, Journal of Pharmaceutical Sciences, Volume:14 Issue: 2, summer 2006
Page:
65
magiran.com/p352447
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یکساله به مبلغ 1,390,000ريال میتوانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
توجه!
- حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران میشود.
- پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانههای چاپی و دیجیتال را به کاربر نمیدهد.
In order to view content subscription is required
Personal subscription
Subscribe magiran.com for 70 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!