TREATMENT OF DIABETIC RATS INDUCED WITH STEROPTOZOTOCIN BY IMMUNOISOLATED TRANSPLANTATION OF ISLET CELLS

Background and Although it is now certain that insulin injection allows us to control the complications resulting from blood sugar imbalances, its accurate control by insulin injection is difficult. Therefore as a logical solution, transplantation of islet cells is globally considered as a treatment and the present study is conducted to verify it. Methods and Materials: After materials preparation, donor tissue was obtained from 6 male wistar rate cage 75-90 days (weight 250-300 gram). Transplantation was done on diabetic rate induced 2-4 weeks earlier by 60 mg/kg streptozotocin intravenous injection. After islet cells transplantation, blood glucose was reduced to normal (145±5 mg/dl) and insulin and C-peptide increased (1.9±0.1 MIU/L and 0.053±0.001 mg/ml respectively). Clinical symptoms of dibetes induction were relieved after transplantation. The technique of islet cells transplantation in the form of encapsulation with the absence of immunological inhibitors to support the graft against the recipient's immunity system is an innovative method to treat type I diabetes.