Assessment of Effect of Glucose Tolerance in Pregnancy Outcome in Patients with Polycystic Ovarian Syndrome

pregnancy is associated with insulin resistance. Eighty percent of obese and 30% of lean women with PCOS (poly cystic ovarian syndrome) demonstrate insulin resistance before conception and as many as 30% are affected by impaired glucose tolerance later in life. As there is paucity of data on the prevalence of carbohydrate impairment during pregnancy and its effect on perinatal outcome and infant morbidity in PCOS patients, this study was designed. In this descriptive analytical study, pregnancy records of 40 PCOS patients were compared with 60 non PCOS patients randomly. All cases in the study and the control group were screened for GDM (Gestational Diabetes Mellitus) with 50 gr glucose challenge test (GCT) in initial weeks and 24-28 week of gestation. Patients with glucose challenge test values of > 140 mg/dl were referred for the 3h /100gr oral glucose tolerance test (GTT). The two groups were then compared for the complications of pregnancy and delivery. BMI was significantly higher in patients in the study group than the control group. Prevalence of GDM and impaired glucose tolerance (IGT) between the groupswas not statistically significance. Prevalence of preeclampcia was significantly higher in PCOS patients than control ones. Prevalence of preterm labor, mode of delivery, mean birth weight, proportion of babies admitted to NICU, placental abruption and placenta previa were not statistically different between two groups. We found no difference in GDM and IGT prevalence in two groups, but prevalence of preeclampcia in patients with this syndrome was higher.