Clinical and Laboratory Features of Patients with IGT in Adults of Region 13 of Eastern Tehran

Individuals with IGT are at an increased risk of developing DM type, II and IGT is a known risk-factor for non-communicable diseases also the risk of cardiovascular disease in these patients is increased. The aim of this study was to determine the features of patients with IGT in Tehran and the correlation of IGT with other variables and risk factors of non-communicable disease. This was a descriptive analytical and cross-sectional study. Out of 9204 participants in the first phase of Tehran lipid and glucose study 960 had IGT. At least 8 weeks later, a second OGTT was done and 331 had IGT. DM and IGT diagnosis were based on WHO criteria. In this group, anthropometric indices, BP, serum glucose, and lipid levels were obtained after 12 hours of fasting. Obesity was defined as BMI >30 kg/m2, over weight BMI 25 to 29. 9 Kg/m2. WHR more than 0. 8 in females and 0. 95 in males were defined as truncal obesity, Hypertension was defined as SBp>_140 or DBp>_90mmHg or taking of anti hypertensive drugs. Statistical analyses were performed using the independent T-test, and ANOVA. Totally 331 patients were studied with IGT, 232 of whom (70%) were female and 99(30%) were male. In 43% of cases BMI was ≥ 30. WHR was abnormal in 83. 7%. Total cholesterol level in 32% was ≥ 240 mg/dl and LDL-C in 28.1% was ≥ 130 mg/dl and in 24.8% was ≥ 160 g/dl. HDL-C in 32. 9% of cases was ≤ 35mg/dl. In 43.2% of cases TG was ≥ 200 mg/dl. Assessment of parameters according to BMI showed that means of cholesterol and triglyceride level in obese patients were higher than the rest (p<0. 42, p<0. 001) and mean of HDL-C in obese patients was lower (p<0. 014). ETT performed in 199 patients (14%) was positive. According to the results of the study, patients with IGT have high risk of cardiovascular events because of multiple risk factors such as obesity, hypertension, smoking, hyper lipidemia