Effects of aqueous extract of fruit of Foeniculum vulgar on neurogenic and inflamatory pain in mice

Results of some of previous investigations showed that the aqueous extract of fruit of the Foeniculum vulgar (FV) has many medical effects. The aim of this study was to assess the role of Aquinus extract of fruit of FV on acute and chronic pain in formalin test in mice. In this study 42 male albino mice of 25-30 gr. weight were devided into 6 groups. FV (100, 200, 500 and 1000 mg/kg) and saline were injected intraperitoneally 30 min before formalin test. The criteria for pain assesment after injection of formalin 5% (25µl) in the right paw of the mice were the durations of licking and elavation of foot (5 min for acute pain and 15-40 min for chronic pain). The results of this study indicated that all doses of Fv have analgesic effect on pain in acute and chronic phases (p<0.05). FV can reduce acute and chronic pain after formalin injection. Further studies are required to determine the mechanism(s) of inhibitory effect of FV on pain sensation.