Efficacy of Clobetasole Under Occlusion in Totalis / Universalis Alopecia

In spite of different tremedial methods for Totalis / Universlis Alopecia ‚ the success in hair regrowth has proved about 25 –30%. There fore, this study was performed to evaluate the efficasy of local clobetasol under occlusion. Materials

I5 cases with Totalis / Universalis Alopecia were treated by this method. The clobetasol dose was 2g daily, using a plastic cover on the scalp. The course lasted for 4 months and patients were visited monthly to evaluate the complications if any .The response was defined as regrowth of 50% terminal hair.

26.6% of cases showed improvemet. Recurrence was seen in only 1 patient, so the success rate was 20% after a 6 month follow-up. The complciations included transient folliculitis in only one case was observed.

It seems that local clobetasol under occlusion is effective in curing Totalis / Universalis Alopecia.