Synthesis of a Biphosphonate (HEDP) as a Bone Imaging Agent with 99mTc

In the last three decades, 99mTc-MDP and 99mTc-HEDP have been used as diagnostic radiopharmaceuticals for bone imaging agents. The radioisotope Department after many investigations decided to develop the synthesis of a biphosphonate derivative, named 1-hydroxy-ethylidene-1, 1-disodium phosphonate (HEDP). In this article, we discuss the method of synthesis, formulation, and labeling of lyophilised kit with 99mTc. The results show that our kit has a high radiochemical purity (>95%), according to the US pharmacopeia. In addition, the stability of lyophilised HEDP kit is more than one year at 4-8oC.