Determination of Drug Resistance Pattern of Prevalent Bacteria Isolated from Patients with UTI

Urinary tract infections are the most prevalent bacterial infections in the world and using empiric antibiotic therapy may increase the drug resistance. This cross- sectional study accomplished to determine the prevalence of UTI and related antibiotic resistance pattern. UTI suspected patients referred to Yazd central laboratory studied. The urine samples cultured colonies with colony count of > 105 cfu/ml identified, and antibiotic resistance patterns determined by the standard disk diffusion method (Kirby-Bauer). Out of 17353 samples 1623 (9.35%) were positive culture. The most prevalent microorganisms were as follows: E.coli (47.07%). Enterobacter (12.07%). S. aureus (10.96%), Klebsiella pneumoniae (9.85%), CNS (8.37%), group B streptococci (4.86%). Enterococci (2.09%). Pseudomonas aeruginosa (1.54%). Proteus (1.17%). Nonhemolytic streptococci (0.86%), Citrobacter and α hemolytic Streptococci (0.55%). The antibiogram results showed that isolated strains had the most drug resistance as follows: to ampicillin (80%), SXT (53.66%), tetracycline (50.33%), cephalexin (22.92%), nalidixic acid (19.4%), nitrofruntain (17.12%), ceftizoxime (8.5%) and ciprofloxacin (8%). Gram (+) cocci strains were 100% sensitive to vancomycin. selection of proper antibiotic against isolated species though susceptibility testing decreases the dissemination of resistant strains.