A Comparison between lipid Per oxidation Products & Hemoglobin in Patients of Diabetes T.2 with Normal People

Oxidative stress and lipid per oxidation occurrence on fatty acids in lipid structure is held to be a significant factor of atherosclerosis problem in diabetic patients. Measuring Malondialdehyde (MDA) as one way, Oxidative stress can be investigated. A total number of 200 people undertook this investigation of whom 100 people (all with a least diabetes history of 3 years ' None Insulin Dependent Diabetic Mellitus" and examination records at cardio-vascular research center of Esfahan university of Medical Sciences) appeared as the "case group". On the other hand, 100 more people with no history of diabetes took part as the " control group". In both the groups, MDA, HbA1c and FBS levels were measured, then the mean plasma levels were compared among them using a Ver.11 SPSS software. According to the results of this study, MDA plasma level was 0.7428±0.04 mol/lit in the "control group", whil it was 0.9222±0.3 mol/lit in the " case group", a statistic difference which was significantly comparable. The FBS level was 163.31±56 mg/dl in the " case group", whereas it was 85.740±10.1 mg/dl in the "control group". These finds all proved a significant difference between the two studied groups, (p>0.05). It is concluded that the mean of MDA in diabetic patients has considerably been higher than that of the "control group". Further more, the mean of HbA1c and FBS in the "case group" was higher than that of the "control group". There was no significant relationship between MDA and the measured factors. At last, we come to the conclusion that no association exists between MDA level and any increase in FBS & HbA1c levels in diabetic patients.