Clinical Effects of Piascledin in the Treatment of Chronic Periodontitis

Considering the role of host inflammatory response in progression of periodontal destruction confirms the host tissue modulation. Piascledin is one of the most medicines decreases periodontal disease symptoms. The aim of this study was evaluating of clinical effects of this herbal medicine in the treatment of chronic periodontitis.Methods and Materials: Twenty for patients with chronic periodontitis were divided in two groups and clinical and radiographic measurements including probing pocket depth (PPD), clinical attachment level (CAL), Plaque index (PI), Bleeding index (BI) and bone density were evaluated. Then phase I of treatment plan was done for all the patients. Test group received piascledine (300 mg) q.d and control group received placebo q.d for 6 months. The patients were recalled at 1, 2, 4 and 6 months for review of the parameters. All of the findings were analyzed by SPSS soft ware with paired t- test. PI, BI, PPD, CAL and bone dentistry had no significant difference between test and control group after 6 months (P = 0.013, P = 0.089, P = 0.861, P = 0.134, P = 0.485, P = 0.864, respectively). The findings of this study dont suggest the use of Piascledine in the treatment of chronic periodontitis; but according to other researches that confirm the effectiveness of this herbal medicine in the treatment of osteoarthritis and periodontitis, it is suggested that other invivo studies should be bone.