Effect of Intensity Training on Plasma Ghrelin Concentration in Male Rats

Ghrelin is a gut hormone predominantly produced by the stomach and, to a lesser extent, by other regions of the gastrointestinal tract. Ghrelin circulates in the bloodstream in two different forms: acylated (n-octanoylated) and unacylated (desoctanoylated or des-acylated). The purposes of this study were to examine the effect of intensity training on plasma ghrelin concentration in Male Rat. Forty adult Wistar male rats (8 weeks old, 280 ± 20 g) were used. Animals were randomly divided into four groups: high intensity (34m/min ~ %85-%90 Vo2max), moderate intensity (28m/min ~ %70-%75 Vo2max), low intensity (20m/min ~ %55-%65 Vo2max), and control groups. All experimental groups performed a 12 week exercise program consisted of treadmill running for 1 hr/day, 5 days/week and 0 gradient. After 12 weeks ghrelin produced was measured. Possible statistically significant differences between groups after intervention was determined by oneway ANOVA, and LSD test was used for a post hoc analysis. Ghrelin concentration increased significantly at high and moderate intensity groups (p<0.05). Data indicate that a higher plasma acylated ghrelin in the present study might be attributed to a liver and skeletal muscle glycogen and ATP deficiency and an incomplete energy sources recovery after last exercise session which was accompanied with overnight fast.