Comparison of combined use of fluconazole and clotrimazole with the sequential dose of fluconazole in the treatment of recurrent Candida vaginitis

fluconazole is one of the systemic anti-fungal agents and clotrimazole vaginal cream is a topical agent against Candida Albicans. In this study, comparison between of the two regimes (Fluconazole with and without vaginal clotrimazole) in recurrent Candida albicans was assessed. with that of sequential dose of fluconazole for the treatment of Candida vaginitis, this evaluation was done. A double blind randomized clinical trial was carried out on 80 married women (20-45 years old) having chronic vaginal Candidiasis. The patients were divided in to two groups (40 in each). The first groups received two doses of fluconazole at two different timing (Zero and 72 hours) along with clotrimazole vaginal cream 1% (for 7 days). The second group recived only two doses of fluconazole (Zero time and 72 hours later). Then the patients were examined at 2 and 6 weeks after the treatment. The signs and symptoms of disease (itching, erythema, excoriation, edema and fissure) in both groups were significantly decreased after two weeks of the treatment (P = 0.00). The final examination of both groups also showed that the treatment was more effective in the first group compared to the second group. The difference was significant statistically (P<0.05). the data shows that adding topical clotrimazole in treatment of patients with recurrent Candida vaginitis Is more effective.