Comparison of Oxidative Stress Content During On-pump and Off-pump Coronary Artery Bypass Surgery

In contrast to conventional on-pump coronary artery bypass grafting (CABG) surgery only mild increase of parameters of oxidative stress is reported during and after off-pump coronary artery bypass grafting. In this study, we attempted to determine the role of off-pump CABG in the myocardial and systemic inflammatory responses. One hundred patients who underwent elective CABG were divided to three groups: 1) patients underwent off-pump CABG or 2) on-pump CABG surgery with controlled reperfusion and 3) on-pump CABG with noncontrolled reperfusion. We took patients systemic venous blood samples for the measurement of serum level malondialdehyde (MDA), TroponinC (cTnI) and total antioxidant (TAC) and blood level superoxiddismotas (SOD), before and after Ischemia and reperfusion. Mean values of decrease left ventricular ejection fraction (LVEF) after surgery in patients group 3 were higher than patients group2 and also (LVEF) in patients group2were higher than patients group1(P<0.0001).There was significant difference in mean increase in CTnI levels among the three study groups (P <0.0001). The Serum concentration of MDA in the patients group3were significantly higher than other two groups (P <0.0001). The decrease SOD, TAC levels in patients patients group3were more than patients patients group2and than patients group1. We conclude that oxidative stress biomarker were increase in on-pump CABG. Controlled reperfusion on-pump CABG in comparison with noncontroled reperfusion on-pump CABG reduces oxidative stress. We conclude that off-pump CABG technique appears to reduce oxidative stress.