Study of Hydatiform Mole Frequency and Some Relative Risk Factors

Introduction & Hydatiform mole is one of the emergency and high risk situations during pregnancy and is defined as swelling and hyperplasia of the placental chorionic villosities. It is histologically characterized by abnormal changes in placental villi including trophoblastic proliferation and stromal edema of villi. Its incidence in different regions of the world is different and various risk factors have been mentioned in different studies. The aim of the present study is determination of frequency of hydatiform mole and some relative factors in Motazedi hospital, Kermanshah. In this descriptive analytic study, medical records of 200 women with the diagnosis of hydatiform mole who were admitted in Motazedi hospital during a 10 year period (1998-2008) were retrospectively reviewed. Also, records of 400 healthy pregnant women who were admitted for delivery were reviewed as control group. The data were analyzed using SPSS software and statistical test including U. mann withney, kelmogrof esmereinof, fischer exact and chi square. In this study frequency of hydatiform mole was 3.1/1000 live birth frequency of complete and incomplete mole were 2.07/1000and 1.04/1000 live birth, respectively. Mean age of patients was 26.33 years. Sixty percent of patients were multipar. History of previous molar pregnancy and irregular menstruation, were significantly effective on frequency of molar pregnancy. (p=0.004,p=0.01 respectively). Molar pregnancy is an emergency situation. There is a high incidence and a high recurrence rate of hydatiform mole in our country. Hydatiform mole should be considered as one of the probable diagnoses women in their reproductive age who refer with bleeding.