Studying efficacy of angioplasty of renal artery on diastolic function of patients with renal artery stenosis

Abstract Backgraound: Renal artery stenosis is a cause of secondary hypertension. Regarding known complication of this disease and possible positive effects of renal artery angioplasty on diastolic function, this study performed among patients with renal artery stenosis. This clinical trial, with before and after design, was performed on 35 eligible patients. Patients with renal artery stenosis (70% stenosis alone, or 50% stenosis with uncontrolled hypertension) which underwent stent– supported precutanous transluminal renal angioplasty (PTRA) were evaluated by Doppler echo and tissue Doppler before and six months after angioplasty. Isovolumic Relaxation Time (IVRT), Deceleration time (DT), E/A, E/Ea and diastolic function were studied. Data were analyzed by Wilcoxon test. 35 patients, including 11 male (31.4 percent) and 24 female (68.6 percent), with mean age (± standard deviation) of 59.6±10.2 years were studied. Renal artery angioplasty doesn’t affect on IVRT and E/A, but it decreased DT and E/Ea to 30.9±54.9 milliseconds (p< 0.002) and 0.44±0.9 (p< 0.04), respectively. It seems that renal artery angioplasty doesn’t alter type of diastolic function, but it decreases E/Ea, as a parameter representing diastolic function.