Corneal Involvement in Xeroderma Pigmentosum: A Histopathologic Report

To specify histopathologic features of corneal involvement in a case with xeroderma pigmentosum (XP).Case Report: A 19-year-old man with a clinical diagnosis of XP presented with bilateral corneal leukoma and decreased visual acuity predominatly in his right eye. Penetrating keratoplasty was performed in the right eye due to severe corneal opacity, vascularization and lipid deposition. The corneal button underwent histopathologic evaluation which disclosed a chronic interstitial lipogranulo-matous keratitis. To our knowledge, this is the first report of corneal involvement in a case with xeroderma pigmentosum in Iran; describing the histopathologic features of the affected cornea in this rare condition.