Evaluation of the Effects of Perioperative Administration of Celecoxib on Pain Management and the use of narcotic after Laparoscopic Cholecystectomy

Introduction & Pain control is one of the main issues in laparoscopic surgeries. Although opioid and non-steroidal anti-inflammatory drugs (NSAIDS) are used for pain control but there are severe side effects, but it is thought that, new generation of NSAIDS are able to control pain without any significant side effects of narcotics. We compared postoperative pain, analgesic administration, duration of hospital stay, and side effect of surgeries such as vomiting. From September 2008 to March 2009, we enrolled 75 laparoscopic cholecystectomy patients in a randomized clinical trial study. The patients were randomly divided into two groups. In intervention group, 200 mg for celecoxib administered one hour before surgery and then 200 mg each 12 hours, for two days after surgery. Placebo was administered in the control group. Then severity of pain was measured by visual analogue score (VAS) every six hours during 48 hours. Opioid consumption, duration of hospital stay, antiemetic usage, and other complications of surgery (such as nausea and vomiting) were recorded. Statistical analysis was performed with SPSS version 16.0. Data were reported as means and SD. Data with normal distribution was tested with independent t-test. Qualitative data was analyzed with chi-square. Means of pain intensity were analyzed with repeated measures anova. P