Effectiveness of the National New-born Screening Program for Congenital Hypothyroidism in Iran

Mental Retardation is the most important complication of congenital hypothyroidism (CH).Early diagnosis and proper treatment have crucial role in prevention of this complication. National new-born screening (NBS) for CH may prevent mental damage in children. This study was aimed to assess the efficacy of NBS for CH in IRAN.

Intelligent Quotient (IQ) of 32 CH patients diagnosed by NBS was compared to 35 controls. Participants were matched regarding age (4-5 years old), gender, and social levels. Two psychological tests (Good enough and Proteus Maze) were used to evaluate the IQ, and means of two tests were calculated and compared. In addition, saved IQ points were calculated.

There is no difference between height, weight and IQ variables for two groups. (105 ±19.03) for cases and (111 ±19.04) for controls. None of participants of both groups has no IQ equal or less than 70. In 1387, totally 2745 CH patients were diagnosed and due to successful management98820 points of IQ were saved.

NBS program is highly effective in Iran. It prevents mental retardation in treated patients by saving normal IQ. Additionally, growth and development faultier is also has been prevented.