Association between IL-12 Receptor beta-1 gene polymorphisms and Tuberculosis between Iranian Population

Tuberculosis (TB) is the most common cause of death due to infectious disease, worldwide. In fact only 10% of people infected with Mycobacterium tuberculosis develop clinical disease which suggests, the role of host genetic factors in susceptibility against TB. For this reason, we aimed to determined IL-12 gene polymorphism among PTB cases. A case-control study was carried out in one hundred twenty TB patient and one hundred sixty seven healthy control individuals. The Single Nucleotide Polymorphism (SNP) in 5 regions of IL12 RB1 gene +705A/G +1158T/C, +1196G/C,+1664C/T and +1637 G/A were determinate by PCR-RFLP. No significance differences were detected at +1664 C/T and +1637 G/A allele frequencies. In this study, the IL-12 gene polymorphism at +1664 C/T and +1637G/A allele were associated with susceptibility against TB. Although, further studies suggested on more number of samples.