Relationship between serum leptin level and parathormone in Continuous Ambulatory Peritoneal Dialysis (CAPD) patients

Leptin is produced by fat cells and is secreted into the blood stream. Serum leptin level is higher in continuous ambulatory peritoneal dialysis (CAPD) patients, compared to the healthy peoples. There are a few studies with controversial results about the relationship between serum leptin level and bone metabolism. The aim of this study was to evaluate the relation between serum leptin level and some bone metabolism factors. In a descriptive-analytical study, 75 CAPD patients in Alzahra Hospital in Isfahan were enrolled from October 2007 to February 2008. Serum levels of leptin, albumin, KT/V, PTH, Ca, P, alkaline phosphates and demographic findings were measured in all patients. Data were using analyzed t-test and the coefficient of correlation. Mean serum leptin level was higher in women compared to men. There was a significant correlation between serum leptin level with body mass index (BMI) (P<0.001). There was no significant correlation between serum leptin level and KT/V, duration of renal failure, serum Ca2+, serum phosphorus and alkaline phosphates. There was a reverse correlation between serum leptin level and serum PTH. Results of this study demonstrated that leptin may have a role in suppression of bone turn over.