The effect of acute physical exercise on serum IL-6 and CRP levels in healthy non-athlete adolescents

The major cytokine involved in the beginning of the acute phase response is IL-6 which causes synthesis of some proteins in the liver like CRP. The purpose of this study is to examine the effect of acute physical exercise on some inflammatory predicting factors of cardiovascular diseases in healthy non-athlete adolescents. We selected 15 non-athlete boys through systematic random sampling among volunteers aged 15.4 ± 0.9 years. First fasting blood samples were collected in the testing session and each subject cycled with 65 to 70% VO2max for 30 minutes. Blood samples were collected to measure HS-CRP and IL-6 immediately after and one hour after completing exercise, respectively. We used analysis of variance with repeated measurements to analyse the data and LSD test to determine the difference among phases. There was a significant increase in interlukine-6 serum values immediately and 60 min after exercise and in reactive protein 60 min after exercise. It was concluded that doing acute physical exercise can lead to an increase in serum IL-6 and CRP in healthy adolescents and with regard to the effect of intensity, duration, exercise type and fitness level on the amount of immune response, there is a need to pay more attention to offering physical exercise leading to fatigue for healthy non-athlete adolescents.