Epidemiologic aspects of cutaneous Leishmaniasis and trapeutic effect of traditional ointment containing onion juice compared with Amphotricin B

Leishmaniasis including visceral and cutaneous types is an endemic disease in some parts of our country. The current study aimed to investigate some epidemiologic aspects of Cutaneous Leishmaniasis (CL) and comparing the effects of a traditional ointment and Amphotricin B. This prospective longitudinal cohort study was conducted to evaluate epidemiologic pattern of CL and comparing different trapeutic agents including Amphotricin B and local traditional ointment containing onion juice in Mehran- Ilam province, Western Iran during 2003-2008. 150 confirmed cases (40 case in topical treatment group and 100 cases in Amphotricin group) out of 925 suspected patients were enrolled into the study. Diagnosis criteria were based on biopsy and microscopic findings. CL prevalence was significantly increased from 16% in 2003 to 25.3% in 2008 (P