The Study of the Effectiveness of Olanzapine as a Maintenance Treatment in Opioid Dependents, a Randomized Clinical Trial

In this research, researchers want to study the effectiveness of Olanzapine on reduction of substance abuse relapse among people who are dependent to opioid material, merely. A randomized clinical trial was designed. The population was opioiddependence subjects (only men) that were diagnosed based on DSM-IV TR criteria, andreferred to national center of addiction studies clinic. Detoxification was done by using ofClonidine, Clonazepam, Disiklomin, and NSAIDS within7 through 10 days. In second stage,the Patients who were referred to the clinic those men who had satisfied criterions selected. Demographic forms, testimonial certificate, Addiction Severity Index, Beck Depression Questionnaire, Zung Self report anxiety test administered among selected sample. Sample divided to two groups (placebo and Olanzapine) the research last for 8 weeks. the results showed that addiction severity reduced in both groups, but there was not significant difference in reduction of addiction severity between two groups. There was significant difference in depression and anxiety among mean scores of base line and follow up in both groups but there was not significant difference between two groups in follow up measures. Altogether, the results did not confirm the effectiveness of Olanzapine on maintenance treatment of opioid dependence.