Effect of Calcitonin Spray in Treatment of Complex Regional Pain Syndrome

Complex regional pain syndrome (CRPS) is a common complication in orthopedic surgeries. The aim of the present study was to evaluate the effect of calcitonin in the treatment of patients with CRPS. In a clinical trial, 30 patients with CRPS were randomly divided into two groups: 16 patients treated with only physiotherapy and 14 patients treated with physiotherapy and calcitonin spray. Changes in range of motion, swelling and pain were compared between two groups. Significant difference was not noted in the range of motion amelioration and decrease in swelling between two groups. However, patients in physiotherapy and calcitonin group had less pain than the other studied group. According to effective pain reduction, patient satisfaction, lack of side effects and insurance coverage for calcitonin, this spray is recommended in the treatment and prevention of CRPS.