Determination of Operational Parameters Effect on the Particles Characteristics in Nano Particles Formation Through RESOLV Method

At the present work, we used the RESOLV (rapid expansion of supercritical solution in to the liquid solvent) method in order to drug nano-particles formation with high solubility rate. This method is specially recommended for producing the biologics, drugs and food material nano-particles because of the middle operational condition. Spraying the supercritical solution into a high dense environment causes fine and uniform paricels formation. Investigation of the jet receiver liquid conditions effects on the formed particles physical properties, is the main goal at this study. Results showed that if the receiver liquid temperature adjusted at below 10°C, non-uniform and crystalline particles whitouth any considerable solubility rate achivment. Apart from the loquid temperature, using a polymeric solution as the receiving liquid affects on the particles properties. The model component at this work is iIbuprofen that is a anti-inflammatory and analgestic drug that always used orally. Decreasing the particles size causes increasing mean particle area and solubility consequently. CO2 which is a reasonable, available, non-flameable and non-toxic gas, with middle supercritical point condition (72 bar and 31/1°C) was used as the supercritical fluid.