Lipoid Proteinosis: A Case Report Urbach & Wiethe Disease

Lipoid proteinosis (LP) is a rare autosomal recessive disease characterized by the deposition of an amorphous hyaline material in the skin، mucosa and viscera. The classic manifestation is onset in infancy with a hoarse cry due to laryngeal infiltration. Skin and mucous changes develope، and the disease follows a slowly progressive course. In this case report، a 49 year-old man presented with a longstanding hoarseness since childhood، dysphagia and asymptomatic skin lesions. Esophageal biopsy showed the deposition of homogenous eosinophilic hyaline-like material compatible with LP.