Effect of Portulaca oleracea L vice versa silver sulfadiazine on burn wound healing in Balb/c mice

The effect of herbal medicine with antitoxidant activity on burn wound healing has been proven in various studies. Portulaca oleracea L (Purslane) is a rich source of antioxidants and fatty acids. This study was carried out to compare the effect of purslane and silver on the second-degree burn wound healing in Balb/c mice. In this preclinical study, burn wounds were made with a hot plate on the back of 85 Balb/c mice. Four groups of mice were treated topically for 21 days by vaseline, silver salfadiazin, 1% and 10% purslane. Wound size on days 0, 7, 14 and 21 were measured. Data were analyzed using Kruskal- Wallis and test. Results showed that the recovery was observed in silver group, 10% purslane, 1% purslane and vaseline, respectively. There was no significant difference in burn wound healing between silver and 10% purslane groups on days 14 and 21 (P>0.05), but significant difference between vaseline and 10% purslane groups on days 14 and 21 (P<0.05). Regarding to the finding of this study, extracts of 10% purslane expedites the wound healing process in mice. Therefor, it might be beneficial in patients with burn wound.