Evaluation the Risk of Metabolic Disorder in Women with Previous Preeclampsia Participated in Tehran Lipid and Glucose Study

Hypertension during pregnancy (HDP) is a gestational disease that occurs mainly among nul‌liparous women, Studies show conflicting results of its complications later in life. We hence aimed to assess metabolic and cardiovascular complications subsequent to preeclampsia in a cohort study.

Normotensive women, participants of the Tehran Lipid Glucose Study (TLGS) were selected and categorized in two groups: Group 1: 226 women with previous preeclampsia as the case group, and 226 age-BMI matched women without preeclampsia as the controls. Groups were followed 10 years and were compared for cardiovascular and metabolic disorders.

The incidence rate of type 2 diabetes mellitus in the case group was 3-fold higher than in controls (37.2% vs 12%). Incidence rates for hypertension and dislipidemia in the case group were also significantly higher than in controls (41.1 vs 19.5% for hypertension and 87.2 vs 66.3% for dislipidemia). Values for systolic blood pressure, fasting blood sugar and high-density lipoprotein (HDL) differed in phase 3 in the two groups.

Women with previous preeclampsia were at high risk of cardiovascular and metabolic disorders. Counseling, screening and providing health care can reduce their complications of preeclampsia, later in life.