The Relationship between Ocular Higher-Order Aberrations and Mesopic Pupil Size with Age and Gender in Iranian Myopic Candidates

To analyze the correlation of ocular higher-order aberrations (HOAs) and mesopic pupil size (MPS) with age and gender in myopic patients screened for refractive surgery Ocular HOAs and MPS were examined in 1,641 females eyes and 749 males eyes with myopia and also in two different age groups, under 30-year-old (1,675 eyes) and over 30-year-old (715 eyes), using the Zywave aberrometer (Busch & Lomb) wavefront aberrometer. Root-mean-square (RMS) values of HOA and MPS were analyzed. All patients had correctable refractive error without history of refractive surgery or underlying diseases. Pupil size measurement was performed under mesopic condition and ocular HOAs were examined across a ≥6.0 mm pupil. The mean value of HOAs in 18-30-year-old group was 0.354±0.137 μm (range, 0.10 to 0.97 μm) and in over 30-year-old group was 0.417±0.158 μm (range, 0.10 to 0.99 μm) (P<0.001). The difference of HOAs between males and females was not significant. The mean value of MPS in 18-30-year-old group was 6.36±0.90 mm (range, 3.1 to 8.9 mm) and in over 30-year-old group was 5.60±0.99 mm (range, 2.8 to 8.5 mm) (P<0.001). The mean value of MPS in females group was 6.10±0.98 mm (range, 2.8 to 8.7 mm) and in males group was 6.20±1.01 mm (range, 2.8 to 8.9 mm) (P=0.010). Significant levels of HOAs were found in our population. The mean value of HOAs in older subjects had statistically significant greater levels, while there was no difference between males and females. Young men had the highest value of MPS.