Compare the Diagnostic Accuracy of Serological and Histology Tests for Helicobacter Pylori in Patients with Dyspepsia and Metabolic Syndrome

Helicobacter pylori infection is a major cause of chronic gastritis especially metabolic syndrome patients. Using accessible and easy methods of diagnosis and treatment of infections with this organism. This study compared two methods of histology and serology for diagnosis of Helicobacter pylori in metabolic syndrome patients has been conducted.
This study was done on 175 metabolic syndrome patients with dyspepsia; referred to Shahroud Imam Hossain hospital which of conducted in 2014. From each patient, with endoscopy were taken standard biopsy and serology test. According to statistic have Sensitivity, specificity, positive and negative predictive.
Of the 175 patients were studied, 90 (51.4%) were male and 85 (48.6%) were female. The mean patient age was 46.9± 18.6 years. From 175 patients, positive serology test were 114 patients (65.1%), and positive histology test were in 149 (85.3%) patients. For serological test, sensitivity was 66.4%, specificity was 42.3%, positive predictive value was 86.8% and negative predictive value was 18.1%. It was also found that, IgG values higher than 1.3 with a sensitivity of 90.7% and specificity of 72.8% was considered positive test. The cutoff point performance test means that was maximum at this point with the AUC: 78.3%, is the highest sensitivity and specificity.
Due to the relative sensitivity and specificity of serological tests in comparison with other diagnostic methods as well as simplicity, speed and low cost of this test, it is recommended that this test be used for metabolic syndrome patients screening.