Efficacy of Hypozalix spray and Propolis mouthwash for prevention of chemotherapy-induced oral mucositis in leukemic patients: A double blind randomized clinical trial

Oral mucositis is the chief complication of head and neck chemotherapy. The current study was conducted to evaluate Hypozalix artificial saliva and propolis mouthwash efficacy for the prevention of chemotherapy-induced oral mucositis in leukemic patients.
The present double-blind clinical trial was carried out on 72 patients, undergoing chemotherapy. The patients were assigned to 3 groups. In the control group, CHX mouthwash and fluconazole were used by the subjects. In groups 1 and 2, Hypozalix and propolis mouthwashes were added to the combination therapy used in the control group. The results were compared between the three groups after 14 days.
Based on the results, 50% of the patients in the control group, 50% in group 1 and 95.8% in group 2 reported recovery from xerostomia. 29.17% of the patients in the control group, 87.5% in group 1 and 70.83% in group 2 exhibited easy mastication. 87.5%, 62.5% and 91.67% of the patients in group 2 exhibited easy swallowing, less waking up and a decrease in burning sensation, respectively(P use of Hypozalix spray or propolis mouthwash in association with CHX mouthwash and fluconazole simultaneously at start of chemotherapy, resulted in a decrease in chemotherapy complications after 14 days. in many cases use of propolis mouthwash yielded better results and the patients exhibited a greater tendency to continue to use it.