Effect of hydro alcoholic extract of Purslane (Portulaca Oleracea L.) on kidney of aging model induced by D-galactose in female mice

This study was conducted to evaluate the effect of Purslane hydro alcoholic extract on blood urea nitrogen (BUN), creatinine (Cr) and kidney histopathology of kidney aging model induced by D-galactose in female mice. In this experimental study, 72 female Naval Medical Research Institute (NMRI) mice (30-35 g) were randomly divided into six groups including: control, Purslane, D-galactose, D-galactose Purslane, Aging and Aging Purslane. The aging model was subcutaneously injected by D-galactose for 45 days, and Purslane hydro alcoholic extract was orally gavaged in the last 21 days. Twenty-four hours after the last treatment, serum samples and kidney tissue were immediately collected to evaluate BUN, Cr and kidney histopathology.There were no significant differences in serum BUN levels between all groups, but Cr levels increased in D-galactose compared to control ( p <0.05) and Aging Purslane compared to Aging group ( p <0.05). Further, D-galactose induced inflammation, tubular dilation, and brush border losses and, administration of Purslane hydro alcoholic extract improved these criteria.The present results indicate that Purslane hydro alcoholic extract has beneficial effects on kidney tissue of aging female mouse model.