Multiple Keratoacanthoma Responsive to Acitretin in an Old Man with Depressed Mood

Keratoacanthoma (KA) is a common neoplasm and one of variety squamous cell carcinoma (SCC) characterized by rapid growth with potential for tissue damage.
A 64-year-old man presented with hyperkeratotic papules that initially appeared on the dorsum of his hand and slowly progressed to form a large annular plaque along with multiple small keratotic plaques and papules. He was depressed and worried about the appearance and lesions. He had a history of multiple surgery on the lesions that had recurrence and finally the surgeon decided to do extensive excision with flap that had recurrence on the donor and recipient site, too. Treatment with Acitretin was started. Evolution of new lesions had decreased and stable lesions had begun to regress.
Although the gold standard for the treatment of keratoacanthoma is surgical excision, oral retinoid can be a good choice for multiple recurrent keratoacanthoma.