EDTA Capped Mn2+ Doped Superparamagnetic Fe3O4 Nanoparticles for Biomedical Application: Development of a Novel Electrosynthesis Route and Characterization

In this work, electrochemical synthesis was applied for the fabrication of ethylenediaminetetraacetic acid (EDTA) capped and metal-cations doped magnetite nanoparticles. The electro-deposition process was performed in the constant current mode using an aqueous electrolyte containing FeCl2.4H2O (0.5 g), Fe(NO3)3 .9H2O (2 g), MnCl2 .6H2O (0.5 g) and 0.2 g EDTA capping agent. The prepared samples were examined by analyses of XRD, IR, TG, EDAX, FE-SEM and VSM. The XRD results proved the magnetite crystal structure of the deposited powder. All chemical bands of EDTA were observed in the IR spectrum of the sample. And EDAX data indicated the doping of iron oxide nanoparticles by Mn2 cations during their electrochemical preparation. Based on the TG results, it was observed that EDTA capped layer has been formed onto the deposited iron oxide particles. The vibrating sample magnetometer (VSM) data (i.e. Ms=41.77 emu g–1, Mr=0.15 emu g–1 and Hc=3.97 G) was also confirmed the super-paramagnetic nature of the EDTA capped iron oxide nanoparticles. Based on the results, the cathodic electrochemical synthesis was proposed as a facile procedure for the preparation of EDTA-coated Mn2 doped SPIONs.