Recurrent and Resistant Torsade de Pointes Due to Methadone Poisoning: A Case Report

Opiate dependence is among the main contributors to diseases worldwide, imposing heavy costs on the healthcare system. As an established approach, substitution therapy by methadone has been long considered as the most effective therapeutic method.
Herein, we present the case of a 40-year-old man, who was referred to the hospital with complaints of sudden and transient loss of consciousness and a history of opiate dependence under methadone therapy, showing recurrent ventricular tachycardia and resistant torsade de pointes.
Poisoning is among the major adverse effects of methadone use, which involves different systems of the body, including the cardiovascular and respiratory systems. Furthermore, effective drugs on QT interval show interferences. Therefore, it is suggested to incorporate relevant recommendations in the new version of the national opiate-dependence therapy protocol.